Bird Eye View of Protein Subcellular Localization Prediction

Protein Subcellular Localization Prediction

ORGANIZATION. Section 1. We first provide the motivation for prediction of protein subcellular localization sites, as well as discuss changes being brought about by progress in proteomics. Section 2. After that, we describe the biology of protein subcellular location. In particular, we explain the principle of protein sorting signals. Section 3. Then we present several experimental techniques f...

Prediction of protein subcellular localization.

Because the protein's function is usually related to its subcellular localization, the ability to predict subcellular localization directly from protein sequences will be useful for inferring protein functions. Recent years have seen a surging interest in the development of novel computational tools to predict subcellular localization. At present, these approaches, based on a wide range of algo...

Protein Subcellular Localization Prediction for Fusarium graminearum∗

The fungal pathogen Fusarium graminearum (telomorph Gibberella zeae) is the causal agent of several destructive crop diseases. Investigating subcellular localizations of F. graminearum proteins can provide insight into pathogenic mechanisms underlying F. graminearum-host interactions. In this paper, we design a novel balanced ensemble classifier based on support vector machines (SVMs) to predic...

Bird ’ s - Eye View Steven

Meta-prediction of protein subcellular localization with reduced voting

Meta-prediction seeks to harness the combined strengths of multiple predicting programs with the hope of achieving predicting performance surpassing that of all existing predictors in a defined problem domain. We investigated meta-prediction for the four-compartment eukaryotic subcellular localization problem. We compiled an unbiased subcellular localization dataset of 1693 nuclear, cytoplasmic...